Cloning and developmental expression of mouse aldehyde reductase (AKR1A4)

The aldo-keto reductase superfamily catalyzes the reduction of a broad rang e of aldehydes and ketones to their corresponding alcohols. Here we report the cloning of the mouse aldehyde reductase cDNA and its embryonic pattern of expression. From stages E7.5 to E13.5 the gene encoding for this enzyme is expressed at high levels in several tissues, including the neural ectode rm, gut endoderm, somites, branchial arches, otic vesicles, limb buds, and tail bud. In adult mice aldehyde reductase was expressed in all tissues exa mined. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.