Possible role of gangliosides in salivary gland complications of diabetes

Authors
Tuzun, E Hatemi, AC Memisoglu, K
Citation
E. Tuzun et al., Possible role of gangliosides in salivary gland complications of diabetes, MED HYPOTH, 54(6), 2000, pp. 910-912
Citations number
24
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MEDICAL HYPOTHESES
ISSN journal
03069877 → ACNP
Volume
54
Issue
6
Year of publication
2000
Pages
910 - 912
Database
ISI
SICI code
0306-9877(200006)54:6<910:PROGIS>2.0.ZU;2-8
Abstract
Gangliosides have previously been considered to be possible antigenic sites in Type 1 diabetes. Lymphocytic infiltration of Langerhans islands is the pathologic hallmark of autoimmune diabetes and may also be observed in sali vary glands in experimental diabetes. Diabetic complications of parotid and submaxillary glands may therefore be related with an autoimmune process ag ainst sialoglycoconjugates of salivary gland tissue. (C) 2000 Harcourt Publ ishers Ltd.