7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

Authors
Ryu, CK Lee, IK Jung, SH Kang, HY Lee, CO
Citation
Ck. Ryu et al., 7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines, MED CHEM RE, 10(1), 2000, pp. 40-49
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
MEDICINAL CHEMISTRY RESEARCH
ISSN journal
10542523 → ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
40 - 49
Database
ISI
SICI code
1054-2523(2000)10:1<40:7SAC>2.0.ZU;2-2
Abstract
6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-( substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5, 8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV3, SK-MEL-2, XF498 and HCT-15. Among th em, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HC T-15 and SK-MEL-2.