S. Sawano et al., Biochemical studies of dopaminergic activation by stimuli of corn oil in the oral cavity in mice, METH FIND E, 22(4), 2000, pp. 223-227
Citations number
36
Categorie Soggetti
Pharmacology & Toxicology
Journal title
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
We investigated the effects of corn oil stimuli in the oral cavity on monoa
minergic neurones by measuring the amount of monoamines and their metabolit
es in brains of mice. Intraoral injection of corn oil (0.1 mi) increased do
pamine (DA) turnover rate in the cortex 3. 5 and 10 min after injection in
mice. A significant increase of DA turnover rate was also observed in midbr
ain 10 min after the corn oil injection. Turnover rates of noradrenaline (N
A) and serotonin (5-HT),were not affected by the corn oil injection in any
of the regions or times rested. In the chronic study, DA and 5-HT contents
in the left and right cortexes and 5-HT contents in diencephalon in the chr
onic corn oil-fed group were significantly higher than those in the-control
but IVA contents were not significantly different between the two groups i
n all regions. In conclusion, the present results suggested that the stimul
i of corn oil in the oral cavity might activate dopaminergic systems in the
bi ain of mice and its chronic stimuli might increase DA contents in the b
rain. Although 5-HT contents increased in the brains of mice by the chronic
corn oil intake, its physiological implication remains to be elucidated. (
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