Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

This review provides both a biological and clinical perspective on Time-Dep endent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuro nal and behavioral effects which strengthen entirely as a function of the p assage of time following even a single or acute exposure. Evidence is prese nted to show that TDS may be involved in the development of a spectrum of d iseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses .