Intraventricular chemotherapy with radiotherapy is the standard treatment o
f leptomeningeal metastasis (LM) from breast cancer; this treatment increas
es median survival only to about 3 months and is frequently complicated by
serious side effects. The authors describe two patients with LM from breast
cancer who were treated with hormonal therapy, which provided a neurologic
response of at least 12 months and a survival of 14+ and 19 months. Hormon
al therapy can be effective and nontoxic for patients with LM from breast c
ancer.