The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study

Authors
Leone, M Attanasio, A Croci, D Filippini, G D'Amico, D Grazzi, L Nespolo, A Bussone, G
Citation
M. Leone et al., The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study, NEUROLOGY, 55(1), 2000, pp. 136-139
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
1
Year of publication
2000
Pages
136 - 139
Database
ISI
SICI code
0028-3878(20000712)55:1<136:TSAMIM>2.0.ZU;2-N
Abstract
In a double-blind study versus placebo, the serotonergic agent m-chlorophen ylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typica l migraine attacks. In the following 24 hours there were more migraines aft er mCPP than after placebo in both groups. These findings are consistent wi th involvement of 5HT(2B,2C,1A) receptor subtypes in the pathophysiology of migraine.