Effects of three cytokine regimens on hematologic recovery and progenitor cell mobilization after high-dose cyclophosphamide, etoposide, and cisplatin

The aim of this study was to compare both the effects on hematologic recove ry and circulating progenitor cell mobilization and the toxicity of three c ytokine regimens administered after high-dose non-myeloablative chemotherap y with cyclophosphamide 5 g/m(2), etoposide 1.5 g/ m(2) and cisplatin 150 m g/m(2). Thirty-five consecutive patients were non-random sequentially alloc ated to one of three treatment groups: (1) granulocyte colony-stimulating f actor alone (n = 15); (2) granulocyte-macrophage colony-stimulating factor alone (n = 10), and (3) sequential interleukin-3 and granulocyte-macrophage colony-stimulating factor (n = 10). Neutrophil recovery in group 1 was sig nificantly hastened as compared to the two other groups (median 2 days, p < 0.005), while no significant differences were observed between groups 2 an d 3. CD34(+) cells peaked about 2 days earlier in group 1 compared to the o ther groups (p = 0.0001), whereas the median peak value of CD34(+) cells wa s similar in the three groups. In all patients, the toxicity related to cyt okine administration was low and easily manageable with nonsteroidal anti-i nflammatory drugs. Copyright (C) 2000 S. Karger AG, Basel.