Genetic aberrations detected by comparative genomic hybridization in ovarian clear cell adenocarcinomas

Genetic abnormalities were detected by comparative genomic hybridization (C GH) in 12 ovarian clear cell adenocarcinomas. DNA sequence copy number abno rmalities (CNAs) occurring in more than 20% of the cancers included increas ed copy numbers of 8q11-q13, 8q21-q22, 8q23, 8q24-qter, 17q25-qter, 20q13-q ter and 21q22-qter and reduced copy numbers of 19p. Increases in copy numbe rs of 8q11-q13, 8q21-q22, 8q23 and 8q24-qter occurred more frequently in di sease-free patients than in recurrent/non-surviving patients (p < 0.05). Ho wever, increases in copy numbers of 17q25-qter and 20q13-qter occurred more frequently in recurrent/non-surviving patients than in disease-free patien ts (p < 0.05). Furthermore, increases in copy numbers of 17q25-qter and 20q 13-qter occurred together (p < 0.05). Additionally, there were negative cor relations between increases in copy numbers of 8q21-q22 and 17q25-qter, and between 8q21-q22 and 20q13-qter (p < 0.05). It appears that ovarian clear cell adenocarcinomas can be classified into two subtypes, one being cancer with an increase in copy numbers of 8q and the other being cancer with incr eases in copy numbers of 17q25-qter and 20q13-qter. Copyright (C) 2000 S. K arger AG, Basel.