Synthesis of enantiomerically enriched alpha-aminophosphinic acid derivatives via asymmetric hydrogenation

Authors
Dwars, T Schmidt, U Fischer, C Grassert, I Krause, HW Michalik, M Oehme, G
Citation
T. Dwars et al., Synthesis of enantiomerically enriched alpha-aminophosphinic acid derivatives via asymmetric hydrogenation, PHOSPHOR SU, 158, 2000, pp. 209-240
Citations number
50
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
158
Year of publication
2000
Pages
209 - 240
Database
ISI
SICI code
1042-6507(2000)158:<209:SOEEAA>2.0.ZU;2-3
Abstract
For the first time, the biological interesting enantiomerically enriched al pha-aminophosphinic acids and their derivatives were prepared by asymmetric hydrogenation of suitable precursors and saponification of the obtained pr oducts. Enantiomeric excesses of up to 99 % were obtained.