LIN-12 and GLP-1 are members of the LIN-12/Notch family of receptors that m
ediate cell-cell interactions during development. The sel-8 gene had been i
dentified previously in a screen for suppressors of a mutation that constit
utively activates LIN-12. Here, we report that sel-8 is essential for lin-1
2- and glp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear
protein. We postulate that SEL-8 serves as a transcriptional coactivator o
r as an assembly factor for transcription complexes that contain the LIN-12
or GLP-1 intracellular domains.