A case with acute renal failure complicated by Waldenstrom's macroglobulinemia and cryoglobulinemia

We encountered a 53-year-old man associated with acute renal failure caused by Waldenstrom's macroglobulinemia and type I cryoglobulinemia. Treatment with prednisolone and cyclophosphamide induced a rapid recovery from acute renal failure. Renal histology revealed endocapillary proliferation and lob ular formation with scattered subendothelial, amorphous and periodic acid-S chiff (PAS)-positive materials in the glomerular capillaries which were pos itive for IgM on immunofluorescence study. Although the exact mechanism for pathophysiology of acute renal failure remains unknown, treatment with pre dnisolone and cyclophosphamide could induce a rapid recovery from acute ren al failure accompanied by Waldenstrom's macroglobulinemia and type I cryogl obulinemia..