An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides

Authors
Nefzi, A Ong, NA Houghten, RA
Citation
A. Nefzi et al., An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides, TETRAHEDR L, 41(29), 2000, pp. 5441-5446
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
29
Year of publication
2000
Pages
5441 - 5446
Database
ISI
SICI code
0040-4039(20000715)41:29<5441:AETSOM>2.0.ZU;2-V
Abstract
An efficient method for the solid-phase synthesis of mono-, di- and triurea s from resin-bound mono-amines, diamines and triamines is described. The ex haustive reduction of solid support-bound amides generated the requisite am ines, which, following treatment with isocyanates and cleavage, provided th e corresponding ureas in high purity and good yields. (C) 2000 Elsevier Sci ence Ltd. All rights reserved.