A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives

Authors
Han, YX Roy, A Giroux, A
Citation
Yx. Han et al., A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives, TETRAHEDR L, 41(29), 2000, pp. 5447-5451
Citations number
37
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
29
Year of publication
2000
Pages
5447 - 5451
Database
ISI
SICI code
0040-4039(20000715)41:29<5447:ADPFSS>2.0.ZU;2-C
Abstract
A versatile protocol for the solid-phase synthesis of highly substituted fu ran derivatives is discussed. This approach employs zincate 1 as the scaffo ld followed by sequential palladium-catalyzed cross-coupling reactions as t he C-C bond-formation step. This methodology allows convenient modification of the furan core in three dimensions, giving rise to structurally diverse derivatives with overall good chemical purity and yield. (C) 2000 Publishe d by Elsevier Science Ltd.