Aberration of chromosomes 8 and 11 in bladder cancer as detected by fluorescence in situ hybridization

Although a bladder cancer-specific abnormality in chromosomes or genes has not been reported, chromosomal regions that tend to become abnormal have be en recognized. In this study, we investigated abnormalities in chromosomes 8 and 11. Then were 27 patients with bladder cancer, 16 males and 11 female s, who participated in this study. Abnormalities in chromosomes 8 and 11 we re investigated by the fluorescence in situ hybridization (FISH) method. Pr obes used in this study were chromosome 8 alpha-satellite and chromosome 11 alpha-satellite (Oncor Co.). Of 27 cases, 15 cases were positive for chrom osome 8 (55.6%) and ten cases were positive for chromosome 11 (37.0%). Sinc e the FISH method detects chromosomal abnormality by the number of signals generated in cancer cells, this method is objective and simple and thus may be applicable in clinical practice.