Association of lymphocytic colitis with linear IgA dermatosis

The case of a 66-year-old female patient is presented, who suffered from ch ronic watery diarrhea. In addition, she developed linear IgA dermatosis aft er oral treatment of a presumed yeast infection with nystatin. To evaluate the reason for her diarrhea, colonoscopy was performed. The macroscopic asp ect of the colon mucosa was described as normal with no specific alteration s for chronic inflammatory bowel disease or for bacterial infections. In co ntrast, the histologic examination revealed the typical characteristics of lymphocytic colitis. This disease is thought to be caused by immunological reactions against as vet unknown luminal antigens. After treatment with steroids and dapsone the diarrhea as well as the skin disease disappeared. To our knowledge, the present report describes for the first time the association of linear IgA dermatosis with lymphocytic colit is after oral treatment with nystatin. A possible causative link between th ese two disease entities is discussed.