Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin

Background Repeat hospitalizations of patients with atherosclerosis represe nt a considerable burden on the health care system. We sought to determine whether clopidogrel compared with aspirin decreases the need for rehospital ization for ischemia and bleeding. Methods and Results The Clopidogrel Versus Aspirin in Patients at Risk of I schemic Events (CAPRIE) trial was a randomized, blinded, multicenter, trial of 19,185 patients with atherosclerotic disease manifested as recent ische mic stroke or myocardial infarction or symptomatic peripheral arterial dise ase. Without any double-counting of events, the number of rehospitalization s for ischemic events (defined as angina, transient ischemic attack, or lim b ischemia) or bleeding events was determined for the entire cohort. There was a significant reduction in the total number of rehospitalizations for i schemic events or bleeding with clopidogrel use compared with aspirin (1502 vs 1673; P = .010) over an average of 1.6 years of treatment. This reducti on in rehospitalization was consistent across individual outcomes of angina , transient ischemic attack, limb ischemia, and bleeding. Compared with asp irin, clopidogrel also resulted in a 7.9% relative risk reduction in a comb ined end point of vascular death, stroke, myocardial infarction, or rehospi talization for ischemic events or bleeding (15.1% to 13.7% at 1 year; P = . 011). Adjusting for baseline prognostic variables, clopidogrel therapy was an independent predictor for reduction of vascular death, stroke, myocardia l infarction, or rehospitalization for ischemic events or bleeding (P = .00 9). Conclusions Treatment with clopidogrel results in a significant decrease in the need for rehospitalization for ischemic events or bleeding compared wi th aspirin. This meaningful end point tracks well with other, more traditio nal measures of outcome and has incremental value beyond such end points.