Magnetic resonance findings and ophthalmologic abnormalities are correlated in patients with neurofibromatosis type 1 (NF1)

In subjects with neurofibromatosis type 1 (NF1), we show that a reduction i n the visual field is the most sensitive indicator of gliomas along the opt ic pathway. Therefore, we conclude that a visual field evaluation is the mo st sensitive clinical test among those evaluated to predict the presence of optic pathway pathology on an MRI examination, These data may contribute t o the establishment of more precise guidelines for the evaluation and treat ment of children with NF1, (C) 2000 Wiley-Liss, Inc.