Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26

Nonspecific X-Iinked mental retardation is a heterogeneous condition consis ting of non-syndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HU GO Human Gene Nomenclature Committee). Two point linkage analysis with 23 i nformative markers gave a lod score of 2.53 at Theta = 0 for markers DXS425 , DXS1254, DIiS1114, and HPRT, (C) 2000 Wiley-Liss, Inc.