Cytomegalovirus-induced tubulointerstitial nephritis in a renal allograft treated by foscarnet therapy

We report a female patient suffering from cytomegalovirus (CMV)-induced tub ulointerstitial nephritis in a renal allograft 70 days after a cadaveric re nal transplantation. CMV-induced renal allograft injury reported in the lit erature mainly related to immune-mediated mechanisms, In our patient, acute tubulointerstitial nephritis, associated with histological evidence of CMV infection, was demonstrated in the renal allograft biopsy. There were no h istological features of allograft rejection, cyclosporin nephrotoxicity nor 'CMV glomerulopathy', She was successfully treated by foscarnet therapy an d a reduction in immunosuppression. Her renal function returned to baseline afterwards, Copyright (C) 2000 S. Karger AG, Basel.