Amiodarone toxicity in a patient with simultaneous involvement of cornea, thyroid gland, and lung

Amiodarone, an iodine-rich benzofuran derivative, is a highly effective age nt for the prophylaxis and treatment of cardiac arrhythmias, but it is asso ciated with numerous side effects. Amiodarone toxicity involving several or gans simultaneously has rarely been reported heretofore. In this report, we describe a case of a 73-year-old man who developed symptomatic hypothyroid ism, pulmonary toxicity, and vortex epitheliopathy of the cornea during 6 m onths of amiodarone therapy for frequent palpitation and angina after myoca rdial infarction. This case illustrates that amiodarone may cause toxicity involving several organs concurrently in a patient receiving term amiodaron e therapy. This may be of clinical significance in managing such patients.