Androgenic sensitivity of polyamine-oxidizing enzyme activities in female rat tissues

Effects of testosterone (10 mu g/100g body weight) on polyamine-oxidizing e nzyme activities in female rat uterus, liver and kidney were demonstrated. Testosterone-treated rats exhibited 2.07 fold (p < 0.002) higher uterine po lyamine oxidase (PAO) activity and 1.93 fold (p < 0.02) higher diamine oxid ase (DAO) activity, as compared to the controls. In the liver, testosterone caused an elevation in PAO (1.39 fold, p < 0.05), but not in DAO activity, whereas in kidney the hormone stimulated DAO (1.30 fold, p < 0.05), but no t PAO activity. The effects observed suggest a possible role for testostero ne in the modulation of polyamine levels in the female organs studied and e specially in uterus.