"Artificial lymphatic system": A new approach to reduce interstitial hypertension and increase blood flow, pH and pO(2) in solid tumors

A mechanical drainage system, the "artificial lymphatic system" (ALS), cons isting of a vacuum source and drain, is evaluated for its ability to aspira te the interstitial fluids responsible for the elevated interstitial fluid pressure (IFP) observed in solid tumors. IFP, pH, and pO(2) radial profiles were measured before and after aspiration using wick-in-needle (WIN) probe s, needle pH and oxygen electrodes, respectively. Laser Doppler flowmetry m easured temporal changes in blood flow rate (BFR) at the tumor surface duri ng aspiration. The WIN probe and IFP profile data were analyzed using numer ical simulation and distributed mathematical models, respectively. The mode l parameter, p(E), reflecting central tumor IFP, was reduced from 15.3 to 5 .7 mm Hg in neuroblastoma and from 13.3 to 12.1 mm Hg in Walker 256, respec tively, following aspiration. The simulation demonstrated that spatial aver aging inherent in WIN measurements reduced the calculated magnitude of the model parameter changes. IFP was significantly lower (p<0.05), especially i n regions surrounding the drain, and BFR was significantly higher (p<0.05) following 25 and 45 min of aspiration, respectively; pH and pO(2) profiles increased following aspiration. The experimental and mathematical findings suggest that ALS aspiration may be a viable way of reducing IFP and increas ing BFR, pO(2) and pH and should enhance solid tumor chemo and radiation th erapy. (C) 2000 Biomedical Engineering Society. [S0090-6964(00)00605-6].