Salvage treatment of advanced non-small-cell lung cancer previously treated with docetaxel-based front-line chemotherapy with irinotecan (CPT-11) in combination with cisplatin
S. Kakolyris et al., Salvage treatment of advanced non-small-cell lung cancer previously treated with docetaxel-based front-line chemotherapy with irinotecan (CPT-11) in combination with cisplatin, ANN ONCOL, 11(6), 2000, pp. 757-760
Background: A phase II study was conducted in order to determine the toxici
ty and efficacy of the combination of CPT-11 and cisplatin, as salvage trea
tment in patients with advanced non-small-cell lung cancer (NSCLC), progres
sing after a docetaxel-based front-line regimen.
Patients and methods: Thirty-one patients (median age 61 years) with NSCLC,
were enrolled. Twenty-six (84%) patients were male, twenty-five (81%) had
disease stage IV, and twenty-eight (90%) had a performance status (WHO) 0-1
. CPT-11 was administered as a 60-minute i.v. infusion at the dose of 100 m
g/m(2) on day 1 and 110 mg/m(2) on day 8; cisplatin was administered at the
dose of 80 mg/m(2) on day 8, after CPT-11 administration. Treatment was re
peated every three weeks.
Results: A total of 110 chemotherapy cycles were administered. In an intent
ion-to-treat analysis 7 patients (23%; 95% confidence interval (95% CI): 8%
-37%) achieved a partial response, 6 (19%) had stable disease, and 18 (58%)
progressive disease. Three of responders had failed a previous docetaxel-c
arboplatin combination. The median duration of response was 3 months, the m
edian TTP 8 months and the median survival for the entire group 8 months. G
rade 3-4 neutropenia was observed in 16 (52%) patients and in two cases thi
s was febrile. Grade 3 and 4 thrombocytopenia occurred in two (7%) patients
, respectively. Grade 3 and 4 diarrhea was seen in 10 (33%) patients, grade
2-3 neurotoxicity in 2 (6%), and fatigue grade 2-3 in 12 (39%). Other toxi
cities were mild.
Conclusions: The combination of CPT-11 and cisplatin has manageable toxicit
y and interesting activity as salvage treatment of patients with advanced N
SCLC, previously treated with a docetaxel-based front-line regimen.