A number of neurological disorders can manifest as isolated pain or as join
t, muscle or bone alterations. These manifestations can raise significant d
iagnostic challenges when they occur early, before the development of neuro
logical and/or radiological abnormalities. This chapter discusses neuropath
ic osteoarthropathies, neurofibromatosis, Parkinson's disease, multiple scl
erosis and the complications of central nervous system lesions.