Bromide kinetics and distribution in the rat. II. Distribution of bromide in the body

The distribution of Br-82-bromide in 15 different organs and tissues of rat s has been determined by high-resolution gamma-ray spectrometry and by the scintillation counting technique at different times after the application o f Na Br-82, either by subcutaneous injection or by continuous administratio n in the drinking water. The amount of Br-82-bromide in the various tissues reached its largest uptake within a few hours, and the concentration ratio of Br-82 in the tissues to blood remained practically constant between 8 a nd 396 h after the applica tion. The whole stomach of rats was the only org an of those investigated that had a larger uptake of Br-82 than blood. Cont rary to some previous findings, the concentration of radiobromide in the th yroid was found not to exceed that in the blood. A remarkably high concentr ation of Br-82 was found in the skin, which represented, because of its lar ge mass, the most abundant depot of bromide in the body of rats. The demons trated excretion of bromide was mainly renal, at a rate of approximately 5% of the administered dose per 24 h.