Wf. Hendry et al., Abdominal relapse in stage 1 nonseminomatous germ cell tumours of the testis managed by surveillance or with adjuvant chemotherapy, BJU INT, 86(1), 2000, pp. 89-93
Objective To assess the impact on patterns of recurrence of adjuvant chemot
herapy in patients with stage 1 nonseminomatous germ cell tumours (NSGCT) o
f the testis. who have a high likelihood of relapse on surveillance if cert
ain risk factors are identified in the orchidectomy specimen. and thus the
theoretical need for retroperitoneal lymph node dissection (RPLND).
Patients and methods The incidence of abdominal relapse was recorded in 417
men presenting with stage 1 NSGCT over the past 18 years, Up to 1986, 161
men were managed by surveillance alone, and abdominal relapse occurred in 2
6. From 1986 onwards, men with positive risk factors in the orchidectomy sp
ecimen were offered two courses of chemotherapy; 60 accepted and one relaps
ed in the abdomen, and 196 underwent surveillance and 19 relapsed in the ab
domen.
Results Abdominal relapse was significantly reduced from 16% before 1986 to
8% afterward (P = 0.014). Mortality from testicular tumour or treatment to
xicity remained low, at 0.6% before 1986 and 2.0% since then.
Conclusion The need for RPLND in stage 1 NSGCT remains highly doubtful.