The relationship between tumor necrosis factor (TNF)-alpha and survival following granulocyte-colony stimulating factor (G-CSF) administration in burn sepsis
E. Arslan et al., The relationship between tumor necrosis factor (TNF)-alpha and survival following granulocyte-colony stimulating factor (G-CSF) administration in burn sepsis, BURNS, 26(6), 2000, pp. 521-524
Blood levels of tumor necrosis factor (TNF)-alpha were determined in 78 pat
ients with burn sepsis. Of these patients, 51 were managed with additional
administration of granulocyte colony-stimulating factor (G-CSF) in addition
to routine treatment procedures (group A), while 27 received only routine
treatment (group B). G-CSF was administrated for at least nine and at most
14 days; doses were gradually decreased in each 3 day period. On the 1st, 4
th, 7th, 10th and 15th days, blood levels of TNF-alpha were determined. We
sought to determine whether TNF alpha levels had a prognostic value in the
management of burn induced sepsis that was treated with G-CSF. in our study
, patients with gradually decreasing TNF-alpha levels in the second 3 day p
eriod, were strong candidates for survival, because TNF-alpha levels decrea
sed little in nonsurvivors but decreased gnarly in survivors. The survival
rate was 42/51 (82.3%) in group A and 9/27 (33.3%) in group B. In conclusio
n, G-CSF had positive effects on survival, and TNF-alpha was a predictor of
prognosis in burn-induced sepsis. (C) 2000 Elsevier Science Ltd and ISBI.
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