Lewis antigen alterations in a population at high risk of stomach cancer

Anomalous Lewis(a) antigen and sulfomucin expression are considered as mark ers of progression in precursor lesions of gastric cancer, Additionally, Le wis antigen and secretor phenotype have been related to Helicobacter pylori infection and gastric epithelial damage, The two objectives of this study were to correlate Lewis antigen alterations with histochemical changes and to explore the relationship between Lewis and secretor phenotypes and gastr ic epithelial damage related to H. pylori infection. The study subjects wer e selected from a chemoprevention trial in Tachira State, Venezuela, an are a with a high risk of gastric cancer. Anomalous Lewis(a) antigen expression in Lewis (a-b+) phenotype individuals was closely related to the severity of the histological lesions, especially to dysplasia and type III intestina l metaplasia lesions. A weak relationship was observed between nonsecretor individuals and more advanced lesions of IM, but this association was not s tatistically significant. There was no relationship between secretor phenot ype and H. pylori status, atrophy, regenerative activity, erosion, or ulcer .