Preparation of fluorine-18 labelled sugars and derivatives and their application as tracer for positron-emission-tomography

The usefulness of F-18-labelled carbohydrates, especially 2-deoxy-2-[F-18]f luoro-D-gluco se, to study pathophysiological processes in man non-invasive ly using positron-emission-tomography (PET) led to a widespread investigati on of different F-18-labelled sugars and sugar derivatives. In consideratio n of the short half-life of fluorine-18 (T-1/2 = 110 min) synthetic strateg ies concerning precursor design, labelling conditions and deprotection of t he intermediate compounds were developed to guarantee an efficient high rad iochemical yield synthesis for diagnostic purposes. Besides some aspects of medical application of 2-deoxy-2-[F-18]fluoro-D-glucose, a few synthetic s trategies are described reflecting development work on promising F-18-label led sugars for diagnostic purposes during the last two decades. (C) 2000 El sevier Science Ltd. All rights reserved.