D. Communi et al., Advances in signalling by extracellular nucleotides: the role and transduction mechanisms of P2Y receptors, CELL SIGNAL, 12(6), 2000, pp. 351-360
Nucleotides are ubiquitous intercellular messengers whose actions are media
ted by specific receptors. Since the first clonings in 1993, it is known th
at nucleotide receptors belong to two families: the ionotropic P2X receptor
s and the metabotropic P2Y receptors. Five human P2Y receptor subtypes have
been cloned so far and a sixth one must still be isolated. In this review
we will show that they differ by their preference for adenine ver-sits urac
il nucleotides and triphospho versus diphospho nucleotides, as well as by t
heir transduction mechanisms and cell expression. (C) 2000 Elsevier Science
Inc. All rights reserved.