Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents

Hydroboration of Wang-supported pent-4-enoic acid 1, followed by transmetal lation with Et2Zn, gives a solid-supported zinc reagent, 2, which undergoes palladium-catalysed coupling with aryl iodides, to give the corresponding 5-arylpentanoic acids 3 in moderate to good yields, after cleavage from the resin using TFA.