Constructive antagonism in limb development

Authors
Dudley, AT Tabin, CJ
Citation
At. Dudley et Cj. Tabin, Constructive antagonism in limb development, CUR OP GEN, 10(4), 2000, pp. 387-392
Citations number
32
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
387 - 392
Database
ISI
SICI code
0959-437X(200008)10:4<387:CAILD>2.0.ZU;2-H
Abstract
Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate lim b is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. O ne key component of this regulatory program appears to be the precise contr ol of signaling by members of the bone morphogenetic protein family via mul tiple antagonistic interactions.