Fixed drug eruptions to human immunodeficiency virus-1 protease inhibitor

Despite numerous drug interactions that occur with human immunodeficiency v irus-1 protease inhibitors, there are relatively few drug reactions. We pre sent two patients receiving saquinavir who developed fixed drug reactions. Both reactions cleared while patients received a therapeutic dose of the me dication, and in one patient a flare was seen when the patient later stoppe d and then restarted the medication. Although fixed drug reactions are rela tively inconsequential, it is important to know that these eruptions may cl ear when the patient is given uninterrupted therapy of a human immunodefici ency virus-1 protease inhibitor, with only post-inflammatory hyperpigmentat ion.