Delayed generalized allergic reactions to corticosteroids

A 37-year-old patient presented with a severe allergic local reaction upon inhalation of budesonide for asthma. Skin tests were positive for budesonid e and amcinonide (group B) and elicited a strong local reaction and a disse minated macular exanthema. Corticosteroids from other groups were well tole rated. A 38-year-old male patient had first an allergic contact dermatitis to topically applied prednisolone acetate and then a disseminated eczematou s exanthema upon oral intake of prednisone. A delayed-type sensitization to corticosteroids from group A such as hydrocortisone, prednisone and tixoco rtol pivalate was identified. A detailed diagnosis in patients with allergi c reactions to corticosteroids is crucial with regard to their use in emerg ency therapy. Copyright (C) 2000 S. Karger AG, Basel.