Influence of acute submaximal exercise on T-lymphocyte suppressor cell function in healthy young men

A defect in T-lymphocyte suppressor cell function has been reported to occu r in a number of autoimmune diseases. The influence of exercise on suppress or cell function has not been determined in individuals with autoimmune dis eases, nor has it been determined in healthy individuals. The purpose of th is investigation was to determine the effect of an acute bout of submaximal exercise on suppressor cell function in healthy males. Each subject (n = 1 0) completed an exercise trial (E; 1 h of cycle ergometry at 70.6% of maxim al oxygen uptake, followed by 2 h of recovery) and a resting trial (R; 3 h of seated rest), separated by at least 1 week. Treatment (E or R) order was counterbalanced. Venous blood samples were obtained pre exercise (PRE), im mediately after exercise (POST), and 2 h post-exercise (2HPOST), and at the same time points in the R trial. Lymphocyte phenotype percentages were det ermined by flow cytometry, while concanavalin-A-induced suppressor cell fun ction was determined on peripheral blood mononuclear cells. No change was o bserved in the percentage of T-cytotoxic/suppressor cells. Suppressor cell function was significantly different between treatments, with the POST E va lue [mean (SD) 56.8 (1.6)%] being higher than the POST R value [41.7 (1.9)% ]. No significant difference was observed 2HPOST. In conclusion, acute subm aximal exercise resulted in a transient increase in suppressor cell functio n in healthy males.