Alternative 5 '-exons of the mouse cAMP-dependent protein kinase subunit RI alpha gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion

The activity of cAMP-dependent protein kinase is controlled by its regulato ry subunits. Mouse RI alpha regulatory subunit expression is initiated from five different non-coding 5'-regions (exons 1a, 1b. 1c, 1d and 1e). This o rganization appears to be conserved among species. All mouse tissues accumu late exon 1a and 1b transcripts and most contain more 1b than 1a, except br ain, heart and oesophagus. Exon 1d and 1e transcripts are found in several tissues, while exon 1c is testis-specific. All five transcripts are in RI a lpha-rich tissues: gonads and adrenal glands. (C) 2000 Federation of Europe an Biochemical Societies. Published by Elsevier Science B.V. All rights res erved.