NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1H-IMIDAZO AND 1H-[1,2,3]-TRIAZOLO FUSED DERIVATIVES

Authors
DELGADO F PASTOR J GARCIANAVIO JL VAQUERO JJ ALVAREZBUILLA J SUNKEL C DECASAJUANA MF PRIEGO JG SANTOS LR STATKOW PR STRAUMANN D
Citation
F. Delgado et al., NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 1H-IMIDAZO AND 1H-[1,2,3]-TRIAZOLO FUSED DERIVATIVES, Il Farmaco, 52(3), 1997, pp. 147-155
Citations number
42
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
3
Year of publication
1997
Pages
147 - 155
Database
ISI
SICI code
0014-827X(1997)52:3<147:NARA-S>2.0.ZU;2-E
Abstract
A series of 1H-Imidazo and 1H-[1,2,3]-Triazolo fused derivatives have been obtained and tested as non peptide AII receptor antagonists. Modi fication of the classical biphenyl moiety to a 4-arylthienyl fragment afforded interesting activities.