THE RADIOPROTECTIVE POWER OF 2-ISOPROPYL 5-METHYL 1,3-THIAZOLANE

The adequate conditions of radioprotective treatment with 2-isopropyl 5-methyl 1,3-thiazolane were established for mice. Protection is maxim um with a unique intraperitoneal injection of LD 50/2, 3 hours prior t o the irradiation. The rate of radiation dose reduction is therefore 1 .75. Survival rate of whole body irradiated mice with supralethal dose s were determined for 11 months. The long term survival of the animals fully proved good prevention of radio-induced damages. In vitro pharm acological studies show the ability of the major metabolite of the com pound to trap organic radicals.