A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn

Authors
Hallouin, F Goupille, C Rocher, J Le Pendu, J
Citation
F. Hallouin et al., A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn, GLYCOCON J, 16(11), 1999, pp. 681-684
Citations number
10
Categorie Soggetti
Biochemistry & Biophysics
Journal title
GLYCOCONJUGATE JOURNAL
ISSN journal
02820080 → ACNP
Volume
16
Issue
11
Year of publication
1999
Pages
681 - 684
Database
ISI
SICI code
0282-0080(199911)16:11<681:AREMFT>2.0.ZU;2-K
Abstract
Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens w ere isolated from a rat colon carcinoma cell line. Expression of the antige ns in normal rat tissues was very restricted and vaccination using Ovine Su bmaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn posit ive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The m odel should be useful for testing new anti-Tn or Sialyl-Tn vaccination prot ocols.