Prognostic value of Y deletion analysis - What is the clinical prognostic value of Y chromosome microdeletion analysis?

In many centres, Y chromosome deletion analysis is still not performed rout inely and if so, the results are used for genetic counselling but are not c onsidered as having a useful prognostic value. The type of deletion (AZFa, b or c) has been proposed as a potential prognostic factor for sperm retrie val in men undergoing TESE, AZFc deletions and partial AZFb deletions are a ssociated with sperm retrieval in similar to 50% of cases while in the case of a patient with complete AZFb deletion the probability of finding mature spermatozoa is virtually nil, Therefore the extent and position of a Y mic rodeletion is important (complete or partial). The prognostic value of Y ch romosome deletion analysis in cases of oligozoospermia is important when on e considers the progressive decrease of sperm number over time in men with AZFc deletions. Cryo-conservation of spermatozoa in these cases could avoid invasive techniques, such as TESE/ICSI, in the future. Male offspring that are conceived by ICSI or IVF techniques from father with oligozoospermia o r azoospermia would also benefit from knowledge of their Y status, since th e identification of the genetic defect will render future medical or surgic al therapies unnecessary. Y microdeletion screening is therefore important, not only to define the aetiology of spermatogenic failure, but also becaus e it gives precious information for a more appropriate clinical management of both the infertile male and his future male child.