Oocyte donation in women cured of cancer with bone marrow transplantation including total body irradiation in adolescence

Female survivors of cancer in childhood and adolescence who have been treat ed with bone marrow transplantation including total body irradiation (TBI) are at high risk of developing ovarian follicular depletion and infertility , The lack of oocytes may be compensated for by oocyte donation but these p atients also seem to have a uterine factor. Even though oestrogen replaceme nt therapy is given, the growth of the uterus during adolescence Is impaire d. To our knowledge there have been no earlier reports of live births after oocyte donation in such patients. We report three cases of oocyte donation in women who, at a young age, were cured of haematological malignancies wi th bone marrow transplantation including TBI. In adolescence they developed ovarian failure and uterine volumes were assessed by ultrasonography, One woman with a uterus of almost normal size delivered a healthy child in the 37th week of gestation. Another woman with severely diminished uterine volu me miscarried in the 17th week of gestation. The third woman has not yet co nceived. Pregnancy achieved by oocyte donation is possible despite TBI in a dolescence. However, the uterine factor is a concern and complications duri ng pregnancy and preterm birth may be expected in these patients.