FUNCTIONAL-ACTIVITY OF LUNG SURFACTANT IN CHRONIC-BRONCHITIS

Lung surfactant (LS) was examined in the course of chronic bronchitis (CB) development in 25 subjects with CB risk factors (RF), 59 with pre bronchitis (PB), 30 with chronic non-obstructive bronchitis (CNOB) and 45 with chronic obstructive bronchitis (COB). Biochemical study of th e expirates covered total phospholipids (TP), fractions of neutral lip ids, several fatty acids (FA), malonic dialdehyde (MDA), antiradical a ctivity (ARA). Development of CB was accompanied with shifts in LS fun ctional activity. In patients with RF the shifts reflected adaptation. In PB, CNOB and COB patients LS got damaged. The damage was detected by biochemical markers: elevated level of polyunsaturated FA, accumula tion of MDA and low ARA.