MAGNESIUM-SULFATE AEROSOL EFFICACY IN BRO NCHIAL-ASTHMA

Action of magnesium sulphate (MS) aerosal (solution osmolality 260 mmo l/l, pH 6.6) on bronchial sensitivity anti reactivity to acetylcholine (AC) and graded exercise as well as bronchial permeability asessed by general plethysmography and pneumotaxography were studied in 49 patien ts with mild and moderate bronchial asthma. It is shown that when comp ared to placebo, MS inhalations conducted in the time of attenuating a sthma exacerbation improved immediate and long-term responses in atopi c and effort asthma. Both in single doses and course administration MS reduced non-specific bronchial hyperreactivity and secretory activity of mast cells. Positive dynamics of bronchoprovocative AC test sugges ted response to treatment in most BA patients.