oCRF and CRF (6-33) depress food but not water intake in the obese Zucker rat

It has previously been demonstrated that oCRF and the CRF binding protein i nhibitor CRF (6-33) reduce body-weight gain in obese Zucker rats. We invest igated whether the reduction in body-weight is attributable to altered feed ing and drinking behaviour. Obese Zucker rats were fitted with osmotic mini -pumps connected to i.c.v. cannulas. Vehicle, oCRF (5 mu g/day) or CRF (6-3 3) (25 mu g/day) were infused for 7 days and the animals observed for an ad ditional 7 days. Body-weight and food and water-intake were recorded daily at 14.00 h. In agreement with published results, oCRF and CRF (6-33) signif icantly reduced body-weight gain in the obese Zucker rat, in addition, food intake was reduced, whereas water consumption was unaffected.