L. Incrocci et al., Low-dose radiotherapy in 179 patients with Peyronie's disease: Treatment outcome and current sexual functioning, INT J RAD O, 47(5), 2000, pp. 1353-1356
Citations number
31
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Purpose: To analyse retrospectively treatment outcome in patients irradiate
d for Peyronie's disease,
Methods and Materials: The records of 179 patients, median age 52 years,tha
t received radiotherapy (RT) between 1982 and 1997 were reviewed. 78% prese
nted with painful erections and 89% with penile deformity. The symptoms wer
e present for a median duration of 6 months (range, 1-72 months). The RT sc
hedule consisted of 13.5 Gy (9 x 1.5 Gy, 3 fractions per week) using orthov
oltage X-rays in 123 patients or 12 Gy (6 x 2 Gy, daily fractions) using el
ectrons in 56 patients. A questionnaire regarding current sexual functionin
g was mailed to 130 patients whose addresses could be traced; 106 (82%) res
ponded,
Results: At mean follow-up period of 3 months, 83% reported that pain was d
iminished or had disappeared after RT, Twenty-three percent of patients rep
orted a decrease in penile deformity. Following RT, surgical correction of
penile curvature was performed in 29% of patients. No RT-related complicati
ons occurred except transient dysuria in 1 patient, Questionnaire data: 72%
of patients were currently sexually active, 48% had erectile dysfunction,
and 49% expressed dissatisfaction with their current sexual functioning.
Conclusion: Low dose external RT (12-13.5 Gy) results in relief of pain in
the majority of patients with Peyronie's disease. Improvement in penile def
ormity was observed, avoiding surgery in a number of patients. No significa
nt RT-associated morbidity was encountered. It is disappointing that almost
50% of patients complain of sexual functioning, but this is presumably not
related to radiotherapy. (C) 2000 Elsevier Science Inc.