Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene

Authors
Mehl, RA Kinsland, C Begley, TP
Citation
Ra. Mehl et al., Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene, J BACT, 182(15), 2000, pp. 4372-4374
Citations number
12
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
182
Issue
15
Year of publication
2000
Pages
4372 - 4374
Database
ISI
SICI code
0021-9193(200008)182:15<4372:IOTECN>2.0.ZU;2-O
Abstract
The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, a n NAD(P) biosynthetic enzyme, has been identified and overexpressed in Esch erichia coli. This enzyme catalyzes the reversible adenylation of nicotinat e mononucleotide and shows product inhibition. The rate of adenylation of n icotinate mononucleotide is at least 20 times faster than the rate of adeny lation of nicotinamide mononucleotide.