Lipid and giant cell poor necrobiotic xanthogranuloma

Citation
S. Kossard et al., Lipid and giant cell poor necrobiotic xanthogranuloma, J CUT PATH, 27(7), 2000, pp. 374-378
Citations number
12
Categorie Soggetti
Dermatology
Journal title
JOURNAL OF CUTANEOUS PATHOLOGY
ISSN journal
03036987 → ACNP
Volume
27
Issue
7
Year of publication
2000
Pages
374 - 378
Database
ISI
SICI code
0303-6987(200008)27:7<374:LAGCPN>2.0.ZU;2-E
Abstract
An 88-year-old man over a 7-month period developed multiple yellow firm foc ally ulcerative papules and nodules over his face, neck and forearms. Seven skin biopsies showed a diffuse infiltrate of epithelioid histiocytes assoc iated with areas of necrosis with neutrophilia. Two biopsies showed xanthog ranulomatous foci, but cholesterol clefts, prominent giant cells or lymphoi d aggregates were not evident. Necrosis with leukocytoclastic debris oversh adowed the presence of hyaline necrobiosis. Ultrastructural examination and oil red-o stains on frozen sections revealed focal lipid vacuoles within h istiocytes. A paraprotein was detected in the patient's serum. This present ation may represent a lipid and giant cell poor variant of necrobiotic xant hogranuloma (NXG) and may potentially lead to a delay in diagnosis.