Anti-inflammatory activities of Trichilia glabra aqueous leaf extract

Trichilia glabra L. aqueous leaf extract exerted a significant antiinflamma tory effect 'in vivo' in the zymosan-induced inflammation model. The extrac t impaired the 'in vitro' activities of polymorphonuclear leukocytes and co mplement, components of mouse immune system closely related to the inflamma tory response induced by zymosan. In particular. a significant reduction in the phagocytic capability and respiratory burst response of mouse polymorp honuclear leukocytes together with an inhibition in the hemolytic activity of mouse complement was observed. (C) 2000 Elsevier Science Ireland Ltd. Al l rights reserved.