Tv. Kondratieva et al., L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas, J EXP CL C, 19(2), 2000, pp. 197-200
Citations number
16
Categorie Soggetti
Oncology
Journal title
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
L-MYC and GSTM1 genotypes were analysed in glioma patients (GP) and healthy
donors (HD). None of these genes appeared to influence the risk of this di
sease, however both polymorphisms correlated with unfavourable clinical par
ameters of gliomas. In particular, S allele of the L-MYC was overrepresente
d in the relapsed patients (P < 0.05), and GSTM1-null genotype was associat
ed with the advanced tumour grade (P < 0.05). Patients, but not donors, dem
onstrated frequent combination of SS L-MYC homozygosity with GSTM1(-) varia
nt (P < 0.01), as well as a correlation between LL L-MYC homozygosity and G
STM1(+) genotype (P < 0.05).