L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas

L-MYC and GSTM1 genotypes were analysed in glioma patients (GP) and healthy donors (HD). None of these genes appeared to influence the risk of this di sease, however both polymorphisms correlated with unfavourable clinical par ameters of gliomas. In particular, S allele of the L-MYC was overrepresente d in the relapsed patients (P < 0.05), and GSTM1-null genotype was associat ed with the advanced tumour grade (P < 0.05). Patients, but not donors, dem onstrated frequent combination of SS L-MYC homozygosity with GSTM1(-) varia nt (P < 0.01), as well as a correlation between LL L-MYC homozygosity and G STM1(+) genotype (P < 0.05).